BD, 340297, PE Mouse Anti-Human CD31 L133.1

The CD31 (Anti-PECAM-1) antibody, clone L133.1, is derived from the fusion of Sp2/0 mouse cells with spleen cells from a BALB/c mouse immunized with purified human natural killer cells.The CD31 (Anti-PECAM-1) antibody recognizes the platelet/endothelial cell adhesion molecule-1 (PECAM-1), a 130 to 140-kilodalton (kDa) single-chain integral membrane glycoprotein that is a member of the immunoglobulin gene superfamily. The CD31 antigen is composed of six extracellular immunoglobulin-like domains belonging to the C2 group. C2 domains are also found in other members of the immunoglobulin superfamily, the cell adhesion molecules (CAMs). The CD31 antigen functions as a vascular cell adhesion molecule and is involved in the process of leucocyte migration through the intercellular junctions of vascular endothelial cells. It may also be involved in thrombosis, angiogenesis, wound healing, and inflammation.