BD, 340651, Anti-bcl-2 PE Bcl-2/100 (also known as 100)

The Anti–bcl-2 antibody, clone 100, is derived from the hybridization of Sp2/0-Ag14 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with the bcl-2α peptide (amino acids 41-54).The Anti–bcl-2 antibody recognizes a 26-kilodalton (kDa) protein encoded by the 230 kb bcl-2 protooncogene. The protein is a regulator of the apoptotic process, and elevated levels can provide resistance to cell death. The bcl-2 protein is expressed in the interior of cells, frequently localized to the mitochondrial membrane.