Description
Recombinant Human MMP-2 antigen produced in E. coli represents human MMP-2 (matrix metalloproteinase 2) containing the entire catalytic N-terminal domain and C-terminal domain. MMP-2 is otherwise known as gelatinase A, a member of a family of secreted zinc-dependent endoproteases, which play a role in the degradation of extracellular matrix (ECM) components, including both fibrillar and non-fibrillar collagens, laminin, basement membrane glycoprotein and fibronectin. MMP-2 specifically cleaves gelatin type I, and types IV, V, VII and X collagens, and is also involved in tissue repair, inflammation, tumour invasion, vasculature angiogenesis, and the rupture of atherosclerotic plaques. Defects in the MMP2 gene are responsible for the autosomal recessive osteolysis disorders known as Torg-Winchester syndrome ( Zankl et al. 2007 ), and multicentric osteolysis nodulosis and arthropathy ( Martignetti et al. 2001 ).
Storage Information
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
