Biolegend, 106903, PE anti-mouse CD217 (IL-17RA) Antibody
25microg
Catalog Number: 106903
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| Verified Reactivity | Mouse |
|---|---|
| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Recombinant mouse IL17-RA/ IL-17 R Fc chimera protein |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Preparation | The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. |
| Concentration | 0.2 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Excitation Laser | Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm) |
| RRID | AB_3083257 (BioLegend Cat. No. 106903) AB_3083257 (BioLegend Cat. No. 106904) |
| Structure |
|---|
| IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex. IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (By similarity) |
| Distribution | Highly expressed in T cells and macrophages and in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) |
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| Function | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity; cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation |
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| Gene ID | 23765 |
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| UniProt | View information about CD217 on UniProt.org |
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| Clone | S19010F |
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| Regulatory Status | RUO |
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| Other Names | IL17-RA, CD217 |
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| Isotype | Rat IgG2b, κ |
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