Biolegend, 142002, Purified anti-mouse CD355 (CRTAM) Antibody
100microg
Catalog Number: 142002
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Manufacturer's Pagewww.biolegend.com/en-us/products/purified-anti-mouse-cd355-crtam-antibody-7411
Description
Class-I MHC-restricted T-cell associated molecule (CRTAM), designated as CD355, is an Ig domain like type I transmembrane receptor, which belongs to the nectin family. In the immune system, CRTAM is strictly expressed on activated NK cells and activated CD8-positive T cells. By binding its ligand Nectin-like molecule 2 (Necl2), CRTAM plays an important role in mediating cell adhesion and migration.
Specifications
General
| Verified Reactivity | Mouse |
|---|---|
| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | CRTAM extracellular region-human IgG Fc fusion protein |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. |
| Application | FC - Quality testedWB - Reported in the literature, not verified in house |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Application Notes | Additional reported applications (for relevant formats) include: Western blotting1. |
| Application References(PubMed link indicates BioLegend citation) | Arase N, et al. 2005. Int. Immunol. 17:1227. (WB) |
| RRID | AB_10899412 (BioLegend Cat. No. 142002) |
| Structure | 75 kD homodimer, nectin family, Ig superfamily |
| Distribution | Activated NK cells and activated CD8-positive T cells |
| Function | Cell adhesion, migration |
| Ligand/Receptor | Nectin-like molecule 2 |
| Cell Type | NK cells, T cells |
| Biology Area | Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction |
| Molecular Family | Adhesion Molecules, CD Molecules |
| Antigen References | 1. Takeuchi A, et al. 2009. J. Immunol. 183:4220. 2. Yeh JH, et al. 2008. Cell 132:846. 3. Arase N. 2005. Int. Immunol. 17:1227. 4. Boles KS, et al. 2005. Blood 106:779. 5. Galibert L, et al. 2005 J. Biol. Chem. 280:21955. 6. Kennedy J, et al. 2000 J. Leukoc. Biol. 67:725. |
| Gene ID | 54698 |
| UniProt | View information about CD355 on UniProt.org |
| Clone | 11-5/CRTAM |
| Regulatory Status | RUO |
| Other Names | Class I-restricted T cell-associated molecule |
| Isotype | Rat IgG2a, κ |
