Biolegend, 389605, APC anti-human CD158k (KIR3DL2) Antibody

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 15 polymorphic KIR genes have been reported in humans. CD158k is a 70 kD three extracellular Ig domain glycoprotein that presents as a disulphide-bonded homodimer extracellularly. The intracellular long cytoplasmic tail of CD158k contains two ITIM domains. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR3DL2 binds to a number of different MHC class 1 molecules depending on the viral peptide sequence presented.