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Description
NR4A2, also known as Nurr1, is a member of the orphan nuclear receptor family 4 subgroup A (NR4A) superfamily. NR4A2 is a transcription factor that regulates expression of the key enzyme required for the synthesis of dopamine and is essential in the differentiation, maturation, and survival of dopaminergic neurons. NR4A2 is involved in the regulation of several neuronal events, including axon outgrowth, neuronal patterning, and terminal differentiation. Mutation or dysregulation of NR4A2 have been linked to brain diseases such as Alzheimer's disease, Schizophrenia, and Parkinson's disease. NR4A2 is pivotal for the function of regulatory T cells and has been found to play regulatory roles in inflammatory arthritis. NR4A2 is expressed at elevated levels in inflamed joint tissues from patients with rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.
Specifications

General

Verified ReactivityMouse
Antibody TypeMonoclonal
Host SpeciesRat
ImmunogenPartial mouse NR4A2 recombinant protein (1-200 a.a.) expressed in E. coli.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
PreparationThe antibody was purified by affinity chromatography.
Concentration0.5 mg/ml
Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C.
ApplicationWB - Quality tested
Recommended UsageEach lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRIDAB_2566567 (BioLegend Cat. No. 682002)
Structure598 amino acids with a predicted molecular weight of 66.6 kD. Contains two zinc finger domains that are responsible for DNA binding.
DistributionNucleus and cytoplasm.
FunctionNR4A2 is a transcription factor, playing important roles in dopaminergic neuron signaling, brain development, and inflammatory responses during arthritis.
InteractionInteracts with PER2, NCOR2, SFPQ, NCOR2, SIN3A, and HADC1.
Biology AreaCell Biology, Neuroscience, Neuroscience Cell Markers, Transcription Factors
Molecular FamilyNuclear Markers
Antigen References1. Liu H, et al. 2015. Neurosci. Lett. 598:85.2. Navone ND, et al. 2014. J. Neuroimmunol. 272:99.3. Chen S, et al. 2013. J. Mol. Neurosci. 51:719.4. Han Y, et al. 2013. Cancer 119:3436.5. Sekiya T, et al. 2011. Nat. Commun. 2:269.6. Aherne CM, et al. 2009. Mol. Immunol. 46:3345.
Gene ID18227
UniProtView information about NR4A2 on UniProt.org
Clone10A4B48
Regulatory StatusRUO
Other NamesNuclear receptor subfamily 4 group A member 2, NUR-related factor 1 (Nurr1), Orphan nuclear receptor NURR1
IsotypeRat IgG2b, κ