Biolegend, 683402, Purified anti-PPARγ Antibody

PPARγ, also known as NR1C3, is a ligand-dependent transcription factor belonging to the peroxisome-proliferator activated receptor (PPAR) family. Upon activation by its ligands, such as fatty acids and prostaglandin PGJ2, PPARγ forms heterodimers with the retinoid X receptors (RXRs) and binds to DNA specific PPAR response elements (PPRE). In the absence of ligand, the PPARγ/RXR heterodimer represses its target genes by recruiting and stabilizing the corepressor complexes at the promoter regions. PPARγ is expressed most abundantly in adipose tissue and induced during adipocyte differentiation. PPARγ has been suggested to regulate the expression of key genes involved in glucose metabolism, lipid storage, energy homeostasis, adipogenesis, atherosclerosis, inflammation, and cancer.