Biolegend, 710456, Recombinant Mouse Ephrin-B2-Fc Chimera (carrier-free)

Ephrins are cell surface molecules with a wide variety of biological functions since they are expressed on nearly every tissue of a developing embryo while also persisting throughout adulthood. The ephrin family of ligands consists of five GPI-linked members (ephrin-A1 through A5) in addition to three transmembrane proteins (ephrin-B1 through B3). The interaction between ephrin ligands and their Eph receptors generates bidirectional signaling, affecting both receptor and ligand expressing cells, and contributes greatly to the regulation of neural crest migration, growth cone development, and cancer progression. Mature Ephrin-B2 is comprised of a 202 amino acid extracellular domain, a 21 amino acid transmembrane portion, and an 83 amino acid cytoplasmic domain. It is expressed on presynaptic neurons where it promotes presynaptic development, EphB2 shedding, and axonal guidance. Ephrin-B2 controls VEGF-induced angiogenesis and lymph angiogenesis by vascular mural cells as well as arterial and lymphatic endothelium. It has also been shown to prevent the effects of NMDA receptor (NMDAR) antibodies on neuroplasticity and memory meant to treat NMDAR encephalitis. Ephrin-B2 overexpression occurs in many cancers where it promotes the metastasis, proliferation, and angiogenesis of tumors. Abnormal Ephrin-B2 upregulation has been characterized in glioblastoma, neuroblastoma, oral squamous cell carcinoma, mutant p53 colorectal carcinoma, and gastric cancers.