Description
Product Usage Information
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting, Immunoprecipitation
Specificity / Sensitivity
MRPL11 Antibody detects endogenous levels of total MRPL11 protein.
Species Reactivity: Human, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile60 of human MRPL11 protein. Antibodies are purified by peptide affinity chromatography.
Background
A subset of mitochondrial proteins are synthesized on the ribosomes within mitochondria (1). The 55S mammalian mitochondrial ribosomes are composed of a 28S small subunit and a 39S large subunit (1). Over 40 protein components have been identified from the large subunit of the human mitochondrial ribosome (1). The mitochondrial ribosomal protein L11 (MRPL11) is one such component (1). In animals, plants and fungi, this protein is translated from a gene in the nuclear genome (2).
Alternate Names
39S ribosomal protein L11, mitochondrial; CGI-113; L11mt; Large ribosomal subunit protein uL11m; MGC111024; Mitochondrial large ribosomal subunit protein uL11m; mitochondrial ribosomal protein L11; MRP-L11; MRPL11; RM11
