Description
Protocol
Available protocols: ELISA+
Specificity / Sensitivity
The PathScan
Species Reactivity: Human
Background
Vinculin is a cytoskeletal protein localized to cell-matrix and cell-cell adhesion complexes with roles in cell adhesion, migration, and signal transduction (1). Metavinculin is a vinculin isoform resulting from alternative splicing containing a 68-residue insert (2). Â Metavinculin is expressed in cardiac and smooth muscle (3), and mutations in the metavinculin insert are associated with various cardiomyopathies (4). Metavinculin protein functions in the cytoskeleton with roles in actin bundling, focal adhesion formation, and cell adhesion and migration (5-7).
Alternate Names
CMD1W; CMH15; epididymis luminal protein 114; epididymis secretory sperm binding protein; HEL114; meta-vinculin; Metavinculin; MV; MVCL; VCL; VINC; Vinculin
