Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
NLRC5 (D9Z5X) Rabbit Monoclonal Antibody recognizes endogenous levels of total NLRC5 protein. This antibody recognizes isoforms 1-6 of NLRC5 protein.
Species Reactivity: Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro131 of human NLRC5 protein.
Background
NLRC5 (NOD-like receptor family CARD domain containing 5, NOD4, CITA, NOD27) is a member of the NLR family of pattern recognition receptors (PRRs) involved in innate immunity (1,2). NLRC5 is predominantly expressed in hematopoietic cells, and is upregulated by IFN-γ (1-4). NLRC5 transcriptionally regulates the MHC class I antigen presentation pathway, and induces the expression of β2 , and genes, in addition to (3-5). In cancer, NLRC5 is critical for inducing cytotoxic CD8 T cell activity and is a potential target for cancer immune evasion (6,7).
Alternate Names
Caterpiller protein 16.1; CLR16.1; FLJ21709; FLJ39711; NLR family CARD domain containing 5; NLR family, CARD domain containing 5; NLRC5; NOD-like receptor C5; NOD27; NOD4; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5
