Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
SLC25A39 (F2F6O) Rabbit Monoclonal Antibody recognizes endogenous levels of total SLC25A39 protein. A band of unknown origin is detected at ~90 kDa.
Species Reactivity: Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SLC25A39 protein.
Background
Members of the solute carrier family 25 (SLC25) transport molecules across the inner mitochondrial membrane (1,2). Mutations in these carriers often result in rare but severe pathologies (3). Solute carrier family 25 member 39 (SLC25A39) and its paralogue SLC25A40 were found to be essential for mitochondrial import of glutathione, thereby protecting against oxidative stress and mitochondrial dysfunction (4,5). Changes in SLC25A39 and SLC25A40 expression were found in cholestasis-associated renal injury and LPS-induced inflammation (6).
Alternate Names
CGI-69; CGI69; FLJ22407; Probable mitochondrial glutathione transporter SLC25A39; S2539; SLC25A39; Solute carrier family 25 member 39; solute carrier family 25, member 39
