Description
Product Usage Information
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody .
Protocol
Available protocols: Western Blotting, Immunoprecipitation
Specificity / Sensitivity
STEEP Antibody recognizes endogenous levels of total STEEP protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human STEEP protein. Antibodies are purified by peptide affinity chromatography.
Background
STING ER exit protein (STEEP) is a highly conserved, ubiquitously expressed protein, which has been shown to be a positive regulator of the cGAS-STING signaling pathway. Mechanistically, research studies have demonstrated that STEEP constitutively interacts with STING to coordinate STING ER-to-Golgi trafficking, which is an essential step to ensure productive STING-dependent signaling and gene expression in response to viral infection (1).
Alternate Names
CXorf56; FLJ22965; MRX107; STEEP1; STING ER exit protein; STING1 ER exit protein 1; UPF0428 protein CXorf56
