Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
TAPBPR (E5P1F) Rabbit Monoclonal Antibody recognizes endogenous levels of total TAPBPR protein.
Species Reactivity: Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with human TAPBPR recombinant protein.
Background
TAPBPR (Tapasin-related protein, TAPBPL) is a type I transmembrane protein expressed primarily in the endoplasmic reticulum (ER) and Golgi apparatus of T cells, B cells, monocytes, and dendritic cells (1,5). TAPBPR acts as a molecular chaperone for major histocompatibility complex class I (MHC class I) and plays a role in the MHC class I-restricted antigen processing and presentation pathway (2-4). TAPBPL has also been described as a novel T cell co-inhibitory molecule and shares both sequence and structural similarities with existing B7 family members of the Ig superfamily (5).
Alternate Names
FLJ10143; TAP binding protein like; TAP binding protein related; TAP binding protein-like; TAP-binding protein-like; TAP-binding protein-related protein; Tapasin-like; TAPASIN-R; Tapasin-related protein; TAPBP-R; TAPBPL; TAPBPR; TPSNR
