Description
Product Usage Information
Western Blotting: 1:1000
Immunoprecipitation: 1:200
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting, Immunoprecipitation
Specificity / Sensitivity
RILP (F1H4O) Rabbit Monoclonal Antibody recognizes endogenous levels of total RILP protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu346 of human RILP protein.
Background
Rab-interacting lysosomal protein (RILP) is an interacting effector of small GTPases in the Rab family, including Rab7 and Rab34, inducing the recruitment of dynein-dynactin motor complexes and regulating late endocytic/lysosomal trafficking (1,2). RILP has also been linked to autophagosome biogenesis and transport (3). Dysregulation of RILP and the Rab complexes have been implicated in neurodegeneration, cancer, and infection (4). RILP can inhibit cell proliferation and invasion and has been reported to function as a tumor suppressor (5,6).
Alternate Names
FLJ31193; PP10141; Rab interacting lysosomal protein; Rab-interacting lysosomal protein; RILP
