Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody .
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
IFI6 Antibody recognizes endogenous levels of total IFI6 protein. This antibody does not cross-react with other ISG12 family proteins.
Species Reactivity: Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IFI6 protein. Antibodies are purified by peptide affinity chromatography.
Background
Interferon alpha-inducible protein 6 (IFI6) belongs to the ISG12 family of proteins and is a small, multipass transmembrane protein localized to mitochondrial membranes (1,2). IFI6 is one of the first interferon-stimulated genes to be identified and research studies have shown that IFI6 regulates apoptotic signaling pathways triggered in response to type-I interferons (3,4). In addition, IFI6 participates in type-I interferon-mediated antiviral signaling by mitigating viral replication (5,6).
Alternate Names
6-16; FAM14C; G1P3; Ifi-6-16; IFI6; IFI616; interferon alpha inducible protein 6; Interferon alpha-inducible protein 6; Interferon-induced protein 6-16; interferon, alpha-inducible protein 6; interferon, alpha-inducible protein clone IFI-6-16
