Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
NCAM2 Antibody recognizes endogenous levels of total NCAM2 protein. This antibody does not cross-react with NCAM1.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro48 of human NCAM2 protein. Antibodies are purified by peptide affinity chromatography.
Background
NCAM (neural cell adhesion molecule) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Two NCAM paralogs ( and ) are encoded in the mammalian genome, which encode NCAM/NCAM1 and NCAM2 proteins, respectively (1,2). As an adhesion molecule with brain-enriched expression, NCAM2 functions to drive axonal targeting, neurite branching, and synaptic development (2-4). is also genetically linked to Down syndrome and may play a role in neurodegenerative diseases such as Alzheimer's disease (2,5).Â
Alternate Names
MGC51008; N-CAM-2; NCAM-2; NCAM2; NCAM21; Neural cell adhesion molecule 2
