Description
Product Usage Information
Western Blotting: 1:1000
Immunofluorescence (Immunocytochemistry): 1:100
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting, Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
CXCL6 (E6V8D) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCL6 protein.
Species Reactivity: Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CXCL6 protein.
Background
C-X-C motif chemokine 6 (CXCL6) is a secreted molecule that belongs to the C-X-C family of chemokines. Research studies have demonstrated that CXCL6 signals through two membrane receptors, CXCR1 and CXCR2, and plays a role in the inflammatory response through its ability to serve as a chemoattractant and activator for neutrophils (1-3). In addition to regulation of the innate immune response via neutrophils, research studies have demonstrated that CXCL6 displays antibacterial properties through disruption of bacteria membrane integrity (3).
Alternate Names
C-X-C motif chemokine 6; C-X-C motif chemokine ligand 6; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); Chemokine alpha 3; CKA-3; CXCL6; GCP-2; GCP2; Granulocyte chemotactic protein 2; SCYB6; small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2); Small inducible cytokine subfamily B (Cys-X-Cys), member b; Small-inducible cytokine B6; Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3
