Description
Product Usage Information
Immunohistochemistry (Paraffin): 1:400
Immunofluorescence (Frozen): 1:400
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 29302 .
Protocol
Available protocols: Immunohistochemistry (Paraffin), Immunofluorescence (Frozen)
Specificity / Sensitivity
Proglucagon (D16G10) Rabbit Monoclonal Antibody recognizes endogenous levels of total proglucagon protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala137 of human proglucagon protein.
Background
Glucose homeostasis is regulated by a variety of hormones, including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver (1,2).
Alternate Names
GCG; Glicentin; Glicentin-related polypeptide; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP-2; GLP1; GLP2; GLUC; Glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; GRPP; Incretin hormone; OXM; OXY; Oxyntomodulin; preproglucagon; Pro-glucagon
