Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
EBNA1-binding protein 2 (F3W6K) Rabbit Monoclonal Antibody recognizes endogenous levels of total EBNA1BP2 protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala239 of human EBNA1BP2 protein.
Background
Epstein-Barr virus (EBV) genomes persist in the proliferating cell nuclei as double-stranded circular DNA plasmids. The replication and segregation of EBV DNA requires a single viral protein, Epstein-Barr nuclear antigen 1 (EBNA1), in addition to cellular factors (1). The ability of EBNA1 to support long-term EBV DNA replication and episome maintenance in cells depends on its interaction with EBNA1-binding protein 2 (EBNA1BP2) (2). EBV infection has been closely linked to the development of various cancer types. EBNA1BP2 has been investigated as a prognostic biomarker for multiple tumor types in pan-cancer analysis (3).
Alternate Names
EBNA1 binding protein 2; EBNA1-binding protein 2; EBNA1BP2; EBP2; homolog of yeast EBNA1-binding protein; NOBP; nuclear FGF3 binding protein; Nucleolar protein p40; P40; Probable rRNA-processing protein EBP2
