Description
Hamilton PRP-3 columns are based on the PRP-1 with a larger pore size for the separation of macromolecules such as DNA, RNA oligos, proteins, peptides, and proteomics. This column resin has no silanol groups, so irreversible protein adsorption is not a concern, giving analytes such as proteins a recovery of > 90%. This stable material also allows the use of concentrated acids, chaotropes, and even detergents to minimize problems with protein solubility. Application Examples: Organic compounds: large molecules (> 2,000 mw), peptides, proteins, protein digests, protected and deprotected oligonucleotides, nucleic acids
