Description
General description
Polymyxin B is a polypeptide antibacterial that belongs to the polymyxin family. It exerts its effects against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter sp., and Klebsiella sp.. Polymyxin B sulfate is a mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
Application
Polymyxin B Sulfate - CAS 1405-20-5 – Calbiochem has been used:
to neutralize the endotoxins in bovine serum albumin
in the in vitro treatment of hepatic stellate cells (HSCs)
as an antibiotic in collateral sensitivity and cross-resistance analysis in Escherichia coli
Biochem/physiol Actions
Polymyxin B possesses antiendotoxin activity. It binds to lipid A of the lipopolysaccharide (LPS) molecules and facilitates penetration by displacing Ca2+ and Mg2+ in the outer membrane of Gram-negative bacteria.
Other Notes
Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
