Description
General description
Prenylated Rab acceptor 1 family protein 2 (PRAF2), or JM4, is a novel 19-kDa transmembrane protein belonging to the PRA1 family. It is highly expressed in the brain, and has been shown to be enriched in synaptic vesicles. PRAF2 is also relatively abundant in the spleen, small intestine, lung, pancreas, as well as various tumors affecting the ovary, breast, and colon. Recent studies have identified PRAF2 as a potential marker for neuroblastoma. Like other PRAF1 proteins, it is localized to the golgi, endoplasmic reticulum, and vesicular structures. The precise role of PRAF2 is not yet clear, but studies suggest that it may play a role in cellular transport processes.
~18 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human Praf2 (JM4).
Application
Anti-Praf2 (JM4) Antibody is an antibody against Praf2 (JM4) for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A representative lot detected Praf2 (JM4) in mouse and human cerebellum tissue and in human breast cancer tissue.
Research Category
Apoptosis & Cancer
Neuroscience
Research Sub Category
Apoptosis - Additional
Synapse & Synaptic Biology
Physical form
Rabbit polyclonal serum containing with 0.05% sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
SK-N-SH cell lysate
Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Praf2 (JM4) in 10 µg of SK-N-SH cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
