Description
General description
Transcription factor MafB (Maf-B) belongs to the bZIP family as a part of the MAF subfamily and contains a characteristic bZIP domain. Maf-B can function as either a transcriptional activator or repressor. It regulates erythroid differentiation through its interaction with and negative regulation of EST-1 activity. Maf-B is a critical factor in the differentiation of islet beta cells, alpha and beta cells, macrophage, monocytic, and podocyte cells. It is involved in macrophage expression and maturation of F4/80, and regulates renal development and survival of renal tubules. Interaction with SUMO regulates the transcriptional activity of Maf-B along with its function in determining macrophage fate. Studies have shown that, relative to cell context, Maf-B can act as either a tumor or an oncogene suppressor.
~ 36 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human Maf-B.
Application
Anti-Maf-B Antibody is a Rabbit Polyclonal Antibody for detection of Maf-B also known as v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) & has been validated in WB, ICC.
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Maf-B in NIH/3T3 cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Physical form
Rabbit polyclonal serum containing 0.05% sodium azide
Unpurified
Preparation Note
Store at -20°C
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
L6 cell lysate
Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Maf-B on 10 µg of L6 cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
