Description
General description
79 kDa observed. Alternative splicing can result in cell type dependent isoforms.
Forkhead Box P1 (FoxP1) is a member of the FOX family of transcription factors. This protein is known to forms homodimers and heterodimers with family members FoxP2 and FoxP4. The forkhead box family has a broad range of functions. These proteins play important roles in immune response, organ development and the development of cancer. The FoxP1 protein is widely expressed and contains both forkhead (winged-helix) and C2H2 zinc finger nucleic acid-binding motifs. At least four different isoforms that result from alternative splicing of the mRNA transcript have been reported.
Immunogen
Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse FoxP1.
Application
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FoxP1 in HeLa and NIH/3T3 cells.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Developmental Signaling
Use Anti-FoxP1 Antibody (Rabbit Polyclonal Antibody) validated in ICC, WB, IHC to detect FoxP1 also known as forkhead box P1, fork head-related protein like B, glutamine-rich factor 1.
Biochem/physiol Actions
This antibody recognizes FoxP1.
Physical form
Unpurified
Unpurified rabbit polyclonal serum with 0.05% sodium azide.
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
RAW264.7 cell lysate
Evaluated by Western Blot in RAW264.7 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP1 on 10 µg of RAW264.7 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
