Merck, ABS94, Anti-MLK1 Antibody
Size:100 μg, Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1, from rabbit, purified by affinity chromatography
Catalog Number: ABS94
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Category
Pack Size100 µg
Description
General description
121 kDa (isoform 1), 123 kDa (isoform 2) calculated
MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.
Immunogen
KLH-conjugated linear peptide corresponding to human MLK1.
Application
Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Colorectal adenocarcinoma tissue
Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
121 kDa (isoform 1), 123 kDa (isoform 2) calculated
MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.
Immunogen
KLH-conjugated linear peptide corresponding to human MLK1.
Application
Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Colorectal adenocarcinoma tissue
Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Specifications
General
| UNSPSC Code | 12352203 |
|---|---|
| NACRES | NA.41 |
| eCl@ss | 32160702 |
| biological source | rabbit |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) |
| NCBI accession no. | NP_149132 |
| UniProt accession no. | P80192 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Quality Level | 100 |
| Gene Information | human ... MAP3K9(4293) |
