Description
PPA HyperCel resin is an industry-scalable chromatography resin designed for protein capture and impurity removal in a biopharmaceutical environment. Operating on a mixed mode mechanism, with a phenlypropylamine ligand, its behavior is based on a combination of electrostatic and hydrophobic interactions of the proteins with the ligands. PPA HyperCel resin provides unique selectivities, different from those given by ion exchange or conventional HIC (hydrophobic interaction chromatography).
PPA HyperCel pre-packed columns are designed to simplify resin screening and selection, making them ideal for optimizing process steps. The RoboColumn®format is particularly suited for high throughput process development (HTPD), allowing for efficient and streamlined purification processes.
Features and Benefits
High mechanical and chemical stability
Suitable for large-scale chromatography in a biopharmaceutical environment
Cross-linked cellulose base matrix
Applications
Protein purification at low ionic strength by direct hydrophobic capture
Separation of challenging mixtures, e.g. protein isoforms or proteins with very close pIs
Orthogonal separation mechanism to ion exchange or HIC
