Abcam, ab278564-100µL, Anti-MEK1 (phospho S221) + MEK2 (phospho S221) antibody [MEK12S221-D3]

Product details
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MEK1 and MEK2 participate in transmitting signals that regulate cell proliferation differentiation and survival. Their role in these processes involves forming part of a signaling complex that includes RAF kinases and ERK1/2. This assembly ensures precise regulation of cell cycle events and growth responses to extracellular signals. The activity of MEK proteins allows cells to modulate responses to external growth factors and stress maintaining cellular homoeostasis. Given their involvement in key biological processes MEK1 and MEK2 are essential for normal cellular function.
Pathways
MEK1 and MEK2 play significant roles in the MAPK/ERK and PI3K/Akt pathways. Their activation by upstream kinases like RAF enables downstream phosphorylation and activation of ERK1/2 key regulators of gene expression and cellular activities. The MAPK/ERK pathway interconnects with other pathways such as the PI3K/Akt pathway creating a network of signals important for cell fate decisions. Through these pathways MEK1 and MEK2 interact with a variety of proteins including PI3K and Akt linking growth factor signaling to broader cellular outcomes.