Abcam, ab319046-100µg, Anti-Dynorphin A antibody [EPR28632-17] - BSA and Azide free

Product details
ab319046 is the carrier-free version of ab319045.
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Dynorphin peptides including Dynorphin A act as modulators of nociceptive pathways influencing the perception of pain. As an agonist of kappa-opioid receptors Dynorphin A produces analgesic effects by inhibiting neurotransmitter release in the central nervous system. Although it does not mainly form part of a complex Dynorphin A may stimulate the release or inhibition of other neurotransmitters such as dopamine affecting mood and stress responses.
Pathways
Several key physiological activities involve Dynorphin A. It influences the opioid system pathway where it plays important roles in pain modulation and mood regulation. Dynorphin A also interacts with the stress response pathways particularly impacting the hypothalamic-pituitary-adrenal (HPA) axis. It shares pathways with other neurotransmitters and proteins such as endorphins and enkephalins which also target opioid receptors.