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Merck, 44583-10MG, Doxorubicin hydrochloride

Size:10 mg, DOX, Hydroxydaunorubicin hydrochloride, suitable for fluorescence, 98.0-102.0% (HPLC)
Available Catalog Numbers
44583-10MG44583-1MG44583-50MG
Catalog Number: 44583-10MG
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Category
Antibiotics & Antimycotics
Pack Size10 mg
TagsCell Culture & AnalysisCell Culture Supplements & ReagentsAntibiotics
CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & BioproductionMerck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification
Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/SIGMA/44583
Description
General description
Chemical structure: tetracycline
Application
Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.
Biochem/physiol Actions
Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Specifications

General

UNSPSC Code51281818
NACRESNA.76
PubChem Substance ID57650234
EC Number246-818-3
Beilstein/REAXYS Number4229251
MDL numberMFCD00077757
InChI1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
SMILES stringCl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI keyMWWSFMDVAYGXBV-RUELKSSGSA-N
biological sourcesynthetic
assay98.0-102.0% (HPLC)
formsolid
colororange to dark red
mp216 °C (dec.) (lit.)
solubilityH2O: 50 mg/mL, clear, orange to red
fluorescenceλem 580-590 nm
suitabilitysuitable for fluorescence
antibiotic activity spectrumneoplastics
mode of actionDNA synthesis | interferes
storage temp.2-8°C
Quality Level200
Gene Informationhuman ... TOP2A(7153)