Merck, 511188-1G, Methyl indole-5-carboxylate

General description
Methyl indole-5-carboxylate (Methyl 1H-indole-5-carboxylate), a substituted 1H-indole, can be prepared by the esterification of indole-5-carboxylic acid. Its efficacy as a substrate for indigoid generation has been assessed.
Application
Methyl indole-5-carboxylate may be used as a reactant in the following processes:
biosynthesis of inhibitors of protein kinases
metal-free Friedel-Crafts alkylation
preparation of diphenylsulfonium ylides from Martin′s sulfurane
cross dehydrogenative coupling reactions
synthesis of indirubin derivatives
preparation of aminoindolylacetates

Methyl indole-5-carboxylate may be used in the preparation of:
methyl indoline-5-carboxylate
1H-indole-5-carbohydrazide
dimethyl 1H-indole-3,5-dicarboxylate