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Merck

Merck, 920487-100MG, 1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-3-carboxylic acid

Size:100 mg, Rigid linker for PROTAC® development
Available Catalog Numbers
920487-100MG920487-50MG
Catalog Number: 920487-100MG
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Category
Carboxylic Acids
Pack Size100 mg
TagsChemistry & BiochemicalsChemical BiologyProtein Degrader Building Blocks
CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & BioproductionMerck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification
Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/ALDRICH/920487
Description
Application
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-3-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920495
920576
920584
ADV638390284
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Specifications

General

MDL numberMFCD34602223
UNSPSC Code12352106
NACRESNA.22
InChI keyBYLRMXBMQIQQBU-UHFFFAOYSA-N
SMILES stringCC(C)(OC(N1CC(C1)CN2C=CC(C(O)=O)=N2)=O)C
formpowder
reaction suitabilityreagent type: linker
functional groupBoc
storage temp.2-8°C
Quality Level100