Merck, 920584-100MG, 5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid

Name: 5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid
Brand: Merck
SKU: 920584-100MG

Size:100 mg, Rigid linker for PROTAC® development

Available Catalog Numbers

920584-100MG 920584-50MG

Catalog Number: 920584-100MG

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Category

Carboxylic Acids

Pack Size100 mg

TagsChemistry & Biochemicals Chemical Biology Protein Degrader Building Blocks

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920487
920495
920576
ADV638390284
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

General

MDL number	MFCD34602227
UNSPSC Code	12352106
NACRES	NA.22
InChI	1S/C13H17N3O4/c1-13(2,3)20-12(19)16-6-8(7-16)9-4-15-10(5-14-9)11(17)18/h4-5,8H,6-7H2,1-3H3,(H,17,18)
InChI key	UMVYLQZBFNQMPM-UHFFFAOYSA-N
SMILES string	CC(C)(OC(N1CC(C2=CN=C(C(O)=O)C=N2)C1)=O)C
form	powder
reaction suitability	reagent type: linker
functional group	Boc
storage temp.	2-8°C
Quality Level	100