Merck, 95271-1G, Vitamin K1

Size:1 g, 2-Methyl-3-phytyl-1, 4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K₁₍₂₀₎, BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers
Available Catalog Numbers
Catalog Number: 95271-1G
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Pack Size1 g
Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/SIGMA/95271
Description
General description
Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.
Application

Nutritional strategies for musculoskeletal health: Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).

Role in coagulation and bone health: A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).

Biochem/physiol Actions
Vitamin K1 plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.
Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Review: Vitamin K and γ-carboxyglutamate biosynthesis; Metabolic functions and mechanism of action
Specifications

General

UNSPSC Code12352205
NACRESNA.79
PubChem Substance ID57653664
EC Number201-564-2
Beilstein/REAXYS Number2568816
MDL numberMFCD00214063
eCl@ss34058015
InChI keyMBWXNTAXLNYFJB-NKFFZRIASA-N
InChI1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
SMILES stringO=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O
biological sourcesynthetic
product lineBioXtra
assay≥99.0% (sum of isomers, HPLC)
formviscous liquid
impurities≤20% cis-isomer
ign. residue≤0.1% (as SO4)
colorlight green-yellow to dark green-yellow
refractive indexn20/D 1.527 (lit.)
mp−20 °C (lit.)
density0.984 g/mL at 25 °C (lit.)
cation tracesAl: ≤5 mg/kg
storage temp.2-8°C
Quality Level200