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Merck, A165-10MG, Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt

Size:10 mg, Rp-Cyclic 3′, 5′-hydrogen phosphorothioate adenosine triethylammonium salt, Rp-cAMPS triethylammonium salt, powder, ≥98% (HPLC)
Available Catalog Numbers
A165-10MGA165-1MGA165-5MG
Catalog Number: A165-10MG
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Category
Membrane Protein Extraction Kits
Pack Size10 mg
CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & BioproductionMerck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification
Description
Application
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt has been used as an antagonist of cAMP to block the cAMP-PKA signal pathway.
Biochem/physiol Actions
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt is capable of inhibiting protein kinase A (PKA).
Rp-Diastereomer of adenosine-3′,5′-cyclic monophosphothioate. Specific membrane-permeable inhibitor of activation by cAMP of cAMP-dependent protein kinase I and II; resistant toward cyclic nucleotide phosphodiesterases; blocks cAMP-mediated effects in numerous systems.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Disclaimer
Extremely hygroscopic. Store desiccated.
Specifications

General

UNSPSC Code41106305
PubChem Substance ID24890575
NACRESNA.77
Web Name Suffix Override≥98% (HPLC), cAMP antagonist, powder
MDL numberMFCD03703495
SMILES stringCCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
InChI1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
InChI keyOXIPZMKSNMRTIV-NVGWRVNNSA-N
assay≥98% (HPLC)
formpowder
storage conditiondesiccated
colorwhite to beige
solubilityH2O: 10 mg/mL
λ<sub>max</sub>258 nm
storage temp.−20°C
Quality Level100