ApplicationGBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:
- to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum
- to study its effects on neurotransmitter release in zebrafish brain
- in DA uptake assay in mice striatal fraction
Biochem/physiol ActionsGBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.
GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.
Features and BenefitsThis compound is featured on the
Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages,
click here.
