Merck, E2375-250MG, Emetine dihydrochloride

Application
Emetine dihydrochloride has been used:
as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life
to study its effects on the stress granules assembly
as a chain-elongation inhibitor in puromycin assay for protein synthesis

Biochem/physiol Actions
Emetine dihydrochloride is a member of the ipecac alkaloids family. It can mediate inhibition of protein and nucleic acid synthesis. It exhibits antiviral activity against dengue virus infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emetine dihydrochloride exhibits anti-proliferative effects against bladder cancer cells. It also possesses anti-protozoal activity.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.