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Merck, E6657-10MG, Eplerenone

Size:10 mg, 9, 11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha, 21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7, 21-dicarboxylic acid, 9, 11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha, 11alpha, 17alpha)-, SC-66110, ≥98% (HPLC)
Available Catalog Numbers
E6657-10MGE6657-50MG
Catalog Number: E6657-10MG
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Category
General Purpose Incubators
Pack Size10 mg
CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & BioproductionMerck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification
Description
General description
Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.
Application
Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.
Biochem/physiol Actions
Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.
Eplerenone is an aldosterone antagonist.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Specifications

General

MDL numberMFCD05662207
UNSPSC Code51111800
PubChem Substance ID329798999
Web Name Suffix Override≥98% (HPLC), aldosterone blocker, powder
NACRESNA.77
SMILES stringO1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C
InChI1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
InChI keyJUKPWJGBANNWMW-VWBFHTRKSA-N
assay≥98% (HPLC)
formpowder
colorwhite to beige
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.2-8°C
Gene Informationhuman ... NR3C2(4306)
Quality Level100