General descriptionLY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
ApplicationLY-294,002 hydrochloride has been used in the inhibition of:
- phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
- autophagy in mesenchymal stem cells (MSCs).
- serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
Biochem/physiol ActionsSpecific cell permeable phosphatidylinositol 3-kinase inhibitor.
Features and BenefitsThis compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured
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Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at
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This compound is featured on the
G Proteins (Heterotrimeric) and
Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages,
click here.
