Merck, SML0493-10MG, T16Ainh-A01

Name: T16Ainh-A01
Brand: Merck
SKU: SML0493-10MG

Size:10 mg, 2-[(5-Ethyl-1, 6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide, ≥95% (HPLC)

Available Catalog Numbers

SML0493-10MG SML0493-50MG

Catalog Number: SML0493-10MG

Pricing

Request a quote.

View RFQ List

Category

Size Exclusion Resins

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/SIGMA/SML0493

Description

Application
T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).
Biochem/physiol Actions
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor...
Features and Benefits
This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Specifications

General

NACRES	NA.77
PubChem Substance ID	329825443
UNSPSC Code	12352200
MDL number	MFCD03278952
InChI	1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
SMILES string	CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
InChI key	QSIYTNYMBWYHAA-UHFFFAOYSA-N
assay	≥95% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	room temp
Quality Level	100