Merck, SML2990-25MG, dCeMM2

Name: dCeMM2
Brand: Merck
SKU: SML2990-25MG

Size:25 mg, 2-((5H-[1, 2, 4]Triazino[5, 6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide, N-(5-Chloro-2-pyridinyl)-2-(5H-1, 2, 4-triazino[5, 6-b]indol-3-ylthio)acetamide, ≥98% (HPLC)

Available Catalog Numbers

SML2990-25MG SML2990-5MG

Catalog Number: SML2990-25MG

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Category

Size Exclusion Resins

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/SIGMA/SML2990

Description

Biochem/physiol Actions
cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase
dCeMM2 is a cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase complex. dCeMM2 induced proximity between CDK12–cyclin K and the CRL complex adaptor protein DDB1 that causes ubiquitination and proteasomal degradation of cyclin K.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
InChI	1S/C16H11ClN6OS/c17-9-5-6-12(18-7-9)20-13(24)8-25-16-21-15-14(22-23-16)10-3-1-2-4-11(10)19-15/h1-7H,8H2,(H,18,20,24)(H,19,21,23)
InChI key	VFWVTIHYVUKNGR-UHFFFAOYSA-N
SMILES string	O=C(NC1=NC=C(Cl)C=C1)CSC2=NC3=C(C4=C(N3)C=CC=C4)N=N2
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C
Quality Level	100