Description
General description
Toremifene is a triphenylethylene derivative. It exhibits antitumor and antiestrogen effects. Toremifene has estrogen-agonist effects on blood lipids and endometrium.
Application
Toremifene citrate salt has been used:
in cell-based ELISA
as a positive control to detect its antiviral activity against Ebola virus (EBOV)
to treat MCF7 and T47D breast cancer cell lines
Biochem/physiol Actions
Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.
