Merck, U104-25MG, UK 14,304

Name: UK 14,304
Brand: Merck
SKU: U104-25MG

Size:25 mg, 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4, 5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

Available Catalog Numbers

U104-25MG U104-5MG

Catalog Number: U104-25MG

Pricing

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Category

General Purpose Incubators

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.
UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture
Biochem/physiol Actions
UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.
Features and Benefits
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

Specifications

General

NACRES	NA.77
PubChem Substance ID	24277812
UNSPSC Code	12352200
MDL number	MFCD00153878
InChI	1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
SMILES string	Brc1c(NC2=NCCN2)ccc3nccnc13
InChI key	XYLJNLCSTIOKRM-UHFFFAOYSA-N
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
Quality Level	100
Gene Information	human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Merck, U104-25MG, UK 14,304

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