Merck, U6508-1MG, UCN-01

Name: UCN-01
Brand: Merck
SKU: U6508-1MG

Size:1 mg, KW-2401, ≥97% (HPLC), powder

Available Catalog Numbers

U6508-1MG U6508-5MG

Catalog Number: U6508-1MG

Pricing

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Category

Phosphatase Inhibitors

Pack Size1 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Manufacturer's Pagewww.sigmaaldrich.com/US/en/product/SIGMA/U6508

Description

Application
UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.
Biochem/physiol Actions
UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.
Features and Benefits
This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	24724639
NACRES	NA.77
Web Name Suffix Override	≥97% (HPLC), PKC inhibitor, powder
MDL number	MFCD26960886
SMILES string	[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8
InChI	1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
InChI key	PBCZSGKMGDDXIJ-HQCWYSJUSA-N
assay	≥97% (HPLC)
form	powder
optical activity	[α]20/D 130 to 160°, c = 0.2 in DMSO
storage condition	protect from light
color	light yellow
solubility	DMSO: >5 mg/mL
storage temp.	2-8°C
Quality Level	100
Gene Information	human ... CDK2(1017), CDK4(1019), CDK6(1021), CHEK1(1111), PDPK1(5170), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683)