Description
Application
cis-Urocanic acid (cis-UCA) has been used:
to study its protective effects on autoimmune encephalomyelitis
in sample preparation to study the distribution of skin chemical components by line illumination Raman microscopy technique in Line-focus illumination mode
as a standard to study the levels of cis-UCA and to check its effect on immune response in multiple sclerosis patients
Biochem/physiol Actions
cis-Urocanic acid (cis-UCA) affects the immune cells of the body and is excreted in the urine due to photoisomerization. It inhibits tumor immunity through photocarcinogenesis in mice. cis-Urocanic acid has been studied to prevent UV-radiation-induced DNA damage leading to skin cancer.
cis-Urocanic acid, a 5-HT agonist, is a product of UV isomerization of trans-urocanic acid in skin, which leads to immunosuppression via activation of 5-HT2A receptor.
Preparation Note
cis-Urocanic acid is soluble in water at a concentration that is greater than 10 mg/ml.
